Tangential Flow Filtration

In order to clarify some beer before filling, we can use different kinds of filters such as plate and frame filters, diatomaceous earth filters, etc. It is usually used in the field of beer brewing equipment. A French customer recently mentioned tangential flow filtration and we searched the internet for some information, which we hope will also help you further in the area of beer brewing equipment.

Tangential Flow Filtration (TFF) is a fast and efficient method for the separation and purification of biological macromolecules. It can be used in a wide range of biological applications such as immunology, protein chemistry, molecular biology, biochemistry and microbiology.TFF can be used to concentrate and desalinate sample solutions in volumes from 10 ml to several thousand liters. It can be used to fractionate large molecules from small biomolecules, harvest cell suspensions, clarify fermentation broths and cell lysates.

Why use tangential flow filtration?

Easy to set up and use – Simply connect the tangential flow filtration device to a pump and manometer with tubing and a few accessories, add the sample to the reservoir, and start filtration.

Fast and efficient – It’s easier to set up and much faster than dialysis. Higher concentrations can be achieved in less time than with centrifugal equipment or stirred cells.

Two steps with one system – Concentrate and percolate one sample on the same system, saving time and avoiding product loss.

Can be scaled up or down – Materials of construction and filter cartridge path lengths allow conditions determined in pilot-scale trials to be applied to process-scale applications. TFF units are available to handle sample volumes as small as 10 mL or as large as several thousand liters.

Economical – TFF devices and boxes can be cleaned and reused, or disposed of after a single use. Simple integrity tests can be performed to confirm that membranes and seals are intact.